ClinVar variant-interpretation velocity, annual

Name: ClinVar variant-interpretation velocity, annual
Creator: ClinVar variant-interpretation velocity
License: https://www.nlm.nih.gov/web_policies.html
Keywords: signals, health, research, yearly

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Annual panel of clinical genomics activity from ClinVar (keyless NCBI E-utilities API): interpretation-record counts per year for 40 curated genes over the trailing 11 completed calendar years, with year-over-year change, share of total ClinVar output, and within-year rank. Track the clinical-sequencing expansion — surging genes, newly characterized conditions, and panel growth. Raw data: U.S. National Center for Biotechnology Information, ClinVar (public domain, 17 U.S.C. 105).

Source: ClinVar variant-interpretation velocity
Rows: 440
Columns: 10
Source cadence: Yearly
Last refreshed: Oct 4, 2026
Theme: health

Column	Type	Description
year	integer	ClinVar record year (PDAT); only completed calendar years are ingested. (unit: year)
gene_symbol	string	HGNC gene symbol of the curated gene (e.g. 'BRCA1', 'CFTR').
gene_panel	string	Clinical panel grouping the gene (hereditary_cancer, cardiovascular, neurodevelopmental, metabolic, pharmacogenomics).
submissions	integer	Number of ClinVar interpretation records for the gene dated to the year (esearch count). (unit: records)
yoy_change	integer	Year-over-year change in submissions vs the previous year (same gene); null for the first year in the window. (unit: records)
yoy_change_pct	float	Year-over-year fractional change (yoy_change / previous-year submissions); null for the first year or when the prior year had zero submissions. (unit: fraction)
share_of_clinvar_pct	float	Share of total ClinVar output in the year taken by this gene (submissions / ClinVar annual total * 100); normalizes for overall ClinVar growth. (unit: percent)
gene_rank	integer	Within-year rank of the gene by submissions (1 = most submitted). (unit: rank)
fetch_date	string	Date this snapshot was fetched (ISO date). (unit: date)
row_hash	string	Deterministic 12-hex row identity hash (year\|gene_symbol).

First 10 sample rows — a preview, not the complete dataset.

year	gene_symbol	gene_panel	submissions	yoy_change	yoy_change_pct	share_of_clinvar_pct	gene_rank	fetch_date	row_hash
2,015	APC	hereditary_cancer	319	—	—	0.615	11	2026-10-04	6a434ea76c81
2,015	ATP7B	metabolic	84	—	—	0.162	28	2026-10-04	235faea59de8
2,015	BRCA1	hereditary_cancer	711	—	—	1.372	5	2026-10-04	38dd9b8897f4
2,015	BRCA2	hereditary_cancer	974	—	—	1.879	1	2026-10-04	50be9d36aaca
2,015	CDH1	hereditary_cancer	158	—	—	0.305	17	2026-10-04	13cb34f97cc6
2,015	CFTR	metabolic	194	—	—	0.374	16	2026-10-04	ee40e729b552
2,015	CYP2C19	pharmacogenomics	9	—	—	0.017	37	2026-10-04	cb553070367b
2,015	CYP2D6	pharmacogenomics	13	—	—	0.025	35	2026-10-04	e1e9dad0bd8a
2,015	DPYD	pharmacogenomics	8	—	—	0.015	38	2026-10-04	81282e392631
2,015	FBN1	cardiovascular	288	—	—	0.556	12	2026-10-04	22f3837d5975

Point any LLM at the metadata endpoint — the documentation above is machine-readable too (JSON-LD + Croissant).

cURL

curl "https://datazimuts.com/v1/datasets/clinvar_variant_velocity/clinvar_interpretation_velocity_annual" | jq '{title, rows, columns_count, license}'

Python

import requests

ds = requests.get("https://datazimuts.com/v1/datasets/clinvar_variant_velocity/clinvar_interpretation_velocity_annual").json()
print(ds["title"], ds["rows"], "rows")

# Sample rows for an LLM context window
for row in ds.get("sample_rows", [])[:5]:
    print(row)

API endpoint: https://datazimuts.com/v1/datasets/clinvar_variant_velocity/clinvar_interpretation_velocity_annual

Tip: fetch /llms.txt for the full machine-readable catalog.

Cite this snapshot

Pinned to snapshot 20261004T073742Z-3050c0d63546 and its content hash, so readers get exactly the data you used.

APA

ClinVar variant-interpretation velocity. (2026). ClinVar variant-interpretation velocity, annual [Data set, snapshot 20261004T073742Z-3050c0d63546, sha256 3050c0d63546]. Datazimuts. Retrieved 2026-10-05, from https://datazimuts.com/en/datasets/clinvar_variant_velocity/clinvar_interpretation_velocity_annual?snapshot=20261004T073742Z-3050c0d63546

BibTeX

@misc{dz_clinvar_variant_velocity_clinvar_interpr_3050c0d6,
  title        = {{ClinVar variant-interpretation velocity, annual}},
  author       = {{ClinVar variant-interpretation velocity}},
  year         = {2026},
  publisher    = {Datazimuts},
  howpublished = {\url{https://datazimuts.com/en/datasets/clinvar_variant_velocity/clinvar_interpretation_velocity_annual?snapshot=20261004T073742Z-3050c0d63546}},
  note         = {Snapshot 20261004T073742Z-3050c0d63546, sha256 3050c0d635461efe781f789d1b65c09e3da7175554e50a8062f851db4e91ee97; accessed 2026-10-05}
}

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ClinVar variant-interpretation velocity, annual

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